ÈËÉú¾ÍÊDz©

EN
ÈËÉú¾ÍÊDz©_Ê×Ò³Èë¿Ú ÈËÉú¾ÍÊDz©_Ê×Ò³Èë¿Ú
ÐÂÎÅÖÐÐÄ
2024-06-03
×îÐÂÑо¿£ºÉ¾³ýÕâ¸ö»ùÒò¿ÉÔöÇ¿NKϸ°û¿¹Ö×Áö»îÐÔ
5ÔÂ30ÈÕ£¬ £¬£¬ÈÕ±¾´óÚæ´óѧµÄÑо¿Ö°Ô±ÔÚImmunityÆÚ¿¯½ÒÏþÁËÌâΪ¡°Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng ¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£¡£¸ÃÑо¿Åú×¢£¬ £¬£¬ÌØÒìÐÔÇóýNKϸ°ûÖеÄmRNAÄÚÇÐøRegnase-1Äܹ»ÔöÇ¿NKϸ°ûµÄϸ°û¶¾ÐÔ»îÐÔºÍ×ÌÈÅËØ-¦Ã£¨IFN-¦Ã£©µÄ±¬·¢£¬ £¬£¬²¢ÔöÌíNKϸ°ûÔÚÖ×Áö×éÖ¯ÄڵĻýÀÛ£¬ £¬£¬´Ó¶øÒÖÖÆÖ×ÁöÉú³¤¡£¡£¡£¡£¡£¡£¸ÃÑо¿Í¹ÏÔÁËÖ×Áö΢ÇéÐÎÖÐNKϸ°û¹¦Ð§Õϰ­µÄÎÊÌ⣬ £¬£¬²¢Ìá³ö°ÐÏòRegnase-1¿ÉÄÜÓÐÖúÓÚÔöÇ¿»îÐÔNKϸ°ûµÄ³¤ÆÚÐÔ£¬ £¬£¬´Ó¶øÔö½ø°©Ö¢ÃâÒßÁÆ·¨µÄÖÎÁÆÐ§¹û¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-06-03
°©Ï¸°û¡°×Ô»Ù¡±Ð·½·¨·¢Ã÷
»¯ÁÆ»áɱËÀ°©Ï¸°û£¬ £¬£¬µ«ÕâЩϸ°ûµÄéæÃü·½·¨ËƺõÓë֮ǰÃ÷È·µÄ²î±ð¡£¡£¡£¡£¡£¡£ºÉÀ¼°©Ö¢Ñо¿ËùÑо¿Ö°Ô±·¢Ã÷ÁËÒ»ÖÖÈ«Ðµİ©Ï¸°ûéæÃü·½·¨£¬ £¬£¬ÓÉSLFN11»ùÒòÆðÖ÷µ¼×÷Óᣡ£¡£¡£¡£¡£Ïà¹ØÑо¿Ð§¹û½üÆÚ½ÒÏþÔÚ¡¶¿ÆÑ§¡·ÔÓÖ¾ÉÏ¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-31
ÐÂÑо¿Ê¹Óüî»ù±à¼­´´Á¢³ö¿¹°©ÄÜÁ¦¸üÇ¿µÄ³¬µÈCAR-Tϸ°û
ÃÀ¹ú¸çÂ×±ÈÑÇ´óѧŷÎÄҽѧÖÐÐĵÄÑо¿Ö°Ô±¿ËÈÕÔÚNature Biotchnology ÆÚ¿¯½ÒÏþÁËÌâΪ¡°Mapping variant effects on anti-tumor hallmarks of primary human T cells with base-editing screens¡± µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£¡£¸ÃÑо¿Ê¹Óüî»ù±à¼­É¸Ñ¡»æÖÆÁËÓ°ÏìÈËÀàÔ­´úTϸ°û¿¹Ö×ÁöЧ¹ûµÄÍ»±äÆ×£¬ £¬£¬·¢Ã÷Á˶ÔCAR-Tϸ°ûÒýÈëPIK3CD»òPIK3R1µÄÌØ¶¨Í»±ä£¬ £¬£¬Äܹ»´´Á¢¾ßÓиüÇ¿¿¹°©ÄÜÁ¦µÄ³¬µÈCAR-Tϸ°û¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-30
¾ÞÊÉϸ°û£º¶Ô¿¹ÊµÌåÖ×ÁöµÄ¡°Ï£ÍûÖ®ÐÇ¡±£¿ £¿£¿
¿ËÈÕ£¬ £¬£¬Öйú¿ÆÑ§ÔºÉîÛÚÏȽøÊÖÒÕÑо¿ÔºÑо¿Ô±À½ÜÍŶÓÓ븴µ©´óѧ´úлÓëÕûºÏÉúÎïѧÑо¿ÔºÑо¿Ô±Íõ¹ÚÁÕÍŶÓÏàÖú£¬ £¬£¬ÏµÍ³»ØÊ×Á˽üÄêÀ´ÈËÌå¾ÞÊÉϸ°û¶àÑùÐÔ¡¢·¢ÓýºÍ¹¦Ð§µÄ×îÐÂÑо¿Ï£Íû£¬ £¬£¬Ìá³ö×ۺϵ¥Ï¸°ûת¼×éѧ¡¢¿Õ¼äת¼×éѧ¡¢ÀàÆ÷¹Ù¹²×÷Óýϵͳ£¬ £¬£¬ÒÔ¼°»ùÓÚÈ˹¤ÖÇÄܵÄÅÌË㹤¾ßµÈÒªÁìÑо¿ÈËÌå×é֯פÁô¾ÞÊÉϸ°ûµÄ×éºÏÕ½ÂÔ¡£¡£¡£¡£¡£¡£Ïà¹ØÑо¿Ð§¹û½ÒÏþÔÚ¡¶ÃâÒßѧÇ÷ÊÆ¡·ÉÏ¡£¡£¡£¡£¡£¡£ÎÄÕÂÖ¸³ö£¬ £¬£¬ÕâÒ»Õ½ÂÔ½«Îª°üÀ¨°©Ö¢ÔÚÄڵľÞÊÉϸ°ûÏà¹Ø¼²²¡ÖÎÁÆÌṩÐÂ˼Ð÷¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-29
ÐÂÑо¿Í¨¹ýµ¥Ï¸°û+AI·¢Ã÷×î¼Ñ¿¹°©Tϸ°û£¬ £¬£¬ÖúÁ¦CAR-TÁÆ·¨
¿ËÈÕ£¬ £¬£¬ÃÀ¹úÐÝ˹¶Ù´óѧµÄÑо¿Ö°Ô±ÔÚNature×Ó¿¯Nature CancerÉϽÒÏþÁËÌâΪ¡°Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling ¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£¡£¸ÃÑо¿·¢Ã÷ÁËÒ»ÖÖ±»³ÆÎªCD8-fit Tϸ°ûµÄ×î¼Ñ¿¹°©Tϸ°ûÑÇȺ£¬ £¬£¬Æä¾ßÓиßǨáãÂʺÍÒ»Á¬É±ÉËÄÜÁ¦£¬ £¬£¬ÓÐÍûÓÃÓÚÔöÇ¿CAR-Tϸ°ûÁÆ·¨µÄ¿¹°©Ð§¹û¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-28
Ç廪´óѧÑо¿ÍŶӿª·¢ÐÂÐÍCAR-Tϸ°û»ò¿É¹¥¿Ë¹ýÃôÐÔÏø´­
5ÔÂ27ÈÕ£¬ £¬£¬Ç廪´óѧ»ù´¡Ò½Ñ§ÔºÅíÃôÍŶÓÔÚNature×Ó¿¯Nature ImmunologyÉϽÒÏþÁËÌâΪ¡°A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice¡±µÄÑо¿ÂÛÎÄ¡£¡£¡£¡£¡£¡£¸ÃÑо¿Éè¼Æ²¢¿ª·¢Á˰ÐÏò¹ýÃô·´Ó¦µÄÓÕ·¢ÒòËØµÄCAR-Tϸ°û¡ª¡ª5TIF4ϸ°û£¬ £¬£¬µ¥´Î×¢ÉäÕâÖÖCAR-Tϸ°ûÄܹ»³¤ÆÚÒÖÖÆÐ¡Êó¹ýÃôÐÔÏø´­µÄ¼£ÏóºÍÖ¢×´¡£¡£¡£¡£¡£¡£ÕâÏîÑо¿»òΪºã¾Ã»º½â¹ýÃôÐÔÏø´­Ìá³öÁËÒ»ÖÖDZÔÚÁÆ·¨¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-27
ÈÕ±¾Ñо¿ÓøÉϸ°ûÅàÓý³ö¿É·Ö½â³É¾«×ÓºÍÂÑ×ÓµÄϸ°û
ÈÕ±¾¾©¶¼´óѧÑо¿Ö°Ô±½üÆÚÔÚÓ¢¹ú¡¶×ÔÈ»¡·ÔÓÖ¾±¨¸æËµ£¬ £¬£¬ËûÃÇ¿ª·¢³öʹÓÃÈËÀàÓÕµ¼¶àÐÑĿϸ°û£¨iPSϸ°û£©´ó×Ú×÷Óý³öǰ¾«Ô­Ï¸°ûºÍÂÑԭϸ°ûµÄÒªÁì¡£¡£¡£¡£¡£¡£ÕâһЧ¹ûÓÐÍûÓÃÓÚÕ¹ÏÖÈËÀàÉúֳϸ°ûµÄÌìÉúÆøÖÆ£¬ £¬£¬Î´À´»¹¿ÉÓÃÓÚÖÎÁƲ»ÔÐÖ¢¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
2024-05-27
ÃæÁÙÐàÂõ£¬ £¬£¬×îÐÂÑо¿·¢Ã÷¹Ç÷À¼¡¿ÉÄÜÔÚ¡°×Ծȡ±
¿ËÈÕ£¬ £¬£¬ÖÐɽ´óѧÖÐɽҽѧԺ½ÌÊÚÕź겨ÍŶÓÓëÏàÖúÕߣ¬ £¬£¬Ê¹Óõ¥Ï¸°û-µ¥ºËת¼×é²âÐòÊÖÒÕ£¬ £¬£¬½¨ÉèÆðÆù½ñϸ°ûÀàÐÍ×îΪÖÜÈ«µÄ¡¢¿çÔ½³ÉÄêÈËÀàÕûÄêËê¶ÎµÄ¹Ç÷À¼¡ÐàÂõÕûºÏͼÆ×£¬ £¬£¬ÆÊÎöÁË×é³É¹Ç÷À¼¡µÄ²î±ðϸ°ûÀàÐͼ°¶àÏî¹Ç÷À¼¡ÐàÂõµ÷Àí»úÖÆ¡£¡£¡£¡£¡£¡£Ïà¹ØÐ§¹û½ÒÏþÓÚ¡¶×ÔÈ»-ÐàÂõ¡·¡£¡£¡£¡£¡£¡£
ÔĶÁ¸ü¶à
¡¾ÍøÕ¾µØÍ¼¡¿